18 articles - From Friday Jun 10 2022 to Friday Jun 17 2022
Guidelines, position statements, white papers, technical reviews, consensus statements, etc…
meta-analyses and systematic reviews
| Nephrol Dial Transplant |
Measuring Quality of Life in Trials Including Patients on Hemodialysis: Methodological Issues Surrounding use of the Kidney Disease Quality of Life Questionnaire. A Systematic Review. Missing data are not dealt with according to the missing data mechanism, which may lead to biased results. Inconsistency in the use of patient reported outcome measures raises questions about the validity of these trials. Methodological issues in nephrology trials could be a contributing factor to why there are limited effective interventions to improve QoL in this patient group. Prospero registration number CRD42020223869. |
RCT, clinical trials, retrospective studies, etc…
| Am J Kidney Dis |
Association of Predicted HLA T-Cell Epitope Targets and T Cell-Mediated Rejection After Kidney Transplantation. Results 277 patients developed TCMR and 134 developed only borderline changes suggestive of TCMR on at least one biopsy. In multivariable analyses, only the PIRCHE-II scores for HLA-DRB1 and HLA-DQB1 were independently associated with the occurrence of TCMR and with allograft failure; this was not the case for HLA class I molecules. If restricted to rejection episodes within the first 3 months after transplantation, only the T-cell epitope targets originating from the donor's HLA-DRB molecular mismatches remain insufficiently suppressed. |
Dipping Status, Ambulatory Blood Pressure Control, Cardiovascular Disease, and Kidney Disease Progression: A Multicenter Cohort Study of CKD. Systolic ABP above goal or the absence of nocturnal dipping, regardless of ABP, were associated with higher risks of cardiovascular disease and kidney disease progression among patients with CKD. |
| Clin J Am Soc Nephrol |
Machine Learning-Derived Integer-Based Score and Prediction of Tertiary Hyperparathyroidism among Kidney Transplant Recipients: An Integer-Based Score to Predict Tertiary Hyperparathyroidism. A simple integer-based score predicted the risk of tertiary hyperparathyroidism in kidney allograft recipients, with improved classification by serial measurement compared with single-time measurement. Clinical trial registry name and registration number Korean Cohort Study for Outcome in Patients with Kidney Transplantation (KNOW-KT), NCT02042963 PODCAST This article contains a podcast at |
| Nephrol Dial Transplant |
Association of coronary artery calcium with adverse cardiovascular outcomes and death in patients with chronic kidney disease: results from the KNOW-CKD. In Korean patients with CKD, CACS was independently associated with adverse cardiovascular outcomes and all-cause death. CACS also showed modest improvements in prediction performance over conventional cardiovascular risk factors. |
Design of the COmbinatioN effect of FInerenone anD EmpaglifloziN in participants with chronic kidney disease and type 2 diabetes using an UACR Endpoint study (CONFIDENCE). CONFIDENCE is evaluating the safety, tolerability and efficacy of dual use of finerenone and a SGLT2i in adults with CKD and T2D. Should an additive effect be shown, early and efficient intervention with dual finerenone and SGLT2i therapy could slow disease progression and provide long-term benefits for people with CKD and T2D. |
Protective effect of sacubitril/valsartan (Entresto®) on kidney function and filtration barrier injury in a porcine model of partial nephrectomy. Fractional sodium excretion increased by Entresto®. Kidney histology and kidney injury molecule-1 in cortex tissue were not different. In conclusion, Entresto® protects the filtration barrier and increases the functional adaptive response of the uninjured kidney. |
Removing race from the CKD-EPI equation and its impact on prognosis in a predominantly White European population. Implementing the 2021 CKD-EPI equation in predominantly White European populations would raise eGFR by a modest amount (larger at older age and men) and shift a major proportion of CKD patients to a higher eGFR category. eGFR by both equations strongly predicted outcomes. |
Salivary potassium measured by genetically encoded potassium ion indicators as a surrogate for plasma potassium levels in hemodialysis patients - a proof-of-concept study. GEPIIs have shown an excellent performance in determining [K+]Saliva. [K+]Plasma and [K+]Saliva exhibited similar kinetics. To determine whether saliva could be a suitable sample type to monitor [K+]Plasma, further testing in future studies are required. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Kidney Int |
Kidney omics in hypertension - from statistical associations to biological mechanisms and clinical applications. The identity of kidney genes, pathways and related mechanisms underlying the genetic associations with BP have started to emerge through integration of genomics with kidney transcriptomics, epigenomics and other omics as well as through applications of causal inference such as Mendelian randomisation. Single cell methodologies further enabled mapping of BP-associated kidney genes to cell-types and in conjunction with other omics - started to illuminate the biological mechanisms underpinning associations of BP-associated genetic variants and kidney genes. Polygenic risk scores derived from genome-wide association studies and refined on kidney omics hold the promise of enhanced diagnostic prediction while kidney omics-informed drug discovery is likely to contribute new therapeutic opportunities for hypertension and hypertension-mediated kidney damage. |
Letters to the editors and authors’ replies
| Am J Kidney Dis |
| Clin J Am Soc Nephrol |
all remaining publications eg case reports, images of the month, etc…
| Clin J Am Soc Nephrol |
| Nat Rev Nephrol |